1P Start + P2 Start = Escape (exits MAME games) 1P Start + Button 1 = Enter (starts a game from MAME menu) 1P Start + Button 3 = P (pauses MAME games)
If you want to add even more alternate functions, simply make your own config file using the instructions included with AutoHotkey. Here is our custom config file that you can modify to add functions.
You can also use AutoHotKey to make macros for complex moves, such as those used in fighting game like Street Fighter. Here are a couple of samples for Street Fighter 4 you can use and customize to your liking or for other characters: